📍Research Results of MVision AI Contour+ Models’ Clinical Evaluation

Key facts:

  • Professionals working in 40 clinics from 31 countries assessed MVision AI’s Contour+ solution (Figure 1).
  • More than 11 800 structures were evaluated on 1353 scans (Figure 2).
  • Detailed results can be found in 5 full text articles published in 3 Peer-reviewed journals (Diagnostics 2020, Physics and Imaging in Radiation Oncology 2022 and 2023, Frontiers in Oncology 2023).
  • Brief data are included in 12 posters or oral presentations from international meetings (IAEA ICARO-3 2021, DEGRO 2022, SEOR 2022, ESTRO 2023, AAPM 2023, Corso di laurea in fisica medicale, 2023) (Table 1).
  • Anatomical sites for which MVision AI models have been used for automatic contouring in the research projects (and the number of studies including them) are: male pelvis (9), breast (4), head and neck (4), thorax (3), female pelvis (3), brain (2), abdomen (2),   heart (2), jaws (1) (Figure 3).
  • The studies evaluated MVision AI contours’ accuracy (14), time save (10), impact on interobserver variability (4), impact on dose (3) (Figure 4).
Figure 1. Geographical distribution of the countries in which studies involving MVision AI’s Contour+ solution were performed (in green)
Figure 2. Number of scans and number of structures, respectively, included in the research projects
Figure 3. Anatomic sites included in research projects that evaluated MVision AI’s models (The number in brackets refers to the corresponding article in the table)
Figure 4. Potential benefits of MVision AI’s Contour+ evaluated in international research projects (The number in brackets refers to the corresponding article in the table)

Table 1. Currently published/presented research projects that involved MVision AI’s Contour+ solution

No. First author (Published/ Presented, year) Title Countries Anatomic Sites No. of scans No. of structures
[1] Kiljunen T (Diagnostics, 2020) A Deep Learning-Based Automated CT Segmentation of Prostate Cancer Anatomy for Radiation Therapy Planning-A Retrospective Multicenter Study Finland

Estonia

Singapore

Male Pelvis 45 290
[2] Olsson CE (Physics and Imaging in Radiation Oncology, 2022) Autosegmentation Based on Different-Sized Training Datasets of Consistently-Curated Volumes and Impact on Rectal Contours in Prostate Cancer Radiation Therapy Sweden Male Pelvis 368 368
[3] Strolin S (Frontiers in Oncology, 2023) How Smart is Artificial Intelligence in Organs Delineation? Testing a CE and FDA Approved Deep-Learning Tool Using Multiple Expert Contours Delineated on Planning CT Iimages Italy Head and neck;

Breast;

Abdomen;

Thorax,

Male pelvis;

Female pelvis

111 7765
[4] Turcas A (Physics and Imaging in Radiation Oncology, 2023) Deep-Learning Magnetic Resonance Imaging-Based Automatic Segmentation for Organs-at-risk in the Brain: Accuracy and Impact on Dose Distribution Romania Brain 30 660
[5] Doolan P (Frontiers in Oncology, 2023) A Clinical Evaluation of the Performance of Five Commercial Artificial Intelligence Contouring Systems for Radiotherapy Cyprus Breast; Head and neck; Thorax

Male pelvis

80 900
[6] Borkvel A (IAEA ICARO-3, 2021) Evaluation of Artificial Intelligence Based Contouring tools in Prostate Cancer Radiation Therapy Planning Estonia Male pelvis 5 40
[7] Morcillo AB (SEOR, 2022) Impact of an Auto-Contouring Software Program on Treatment Preparation Time Spain all 432 NA
[8] Ehrhardt V (DEGRO, 2022)* The Possibility of AI-based Contours for Automatic Target Volume Determination in the Irradiation of Localized Prostate Carcinoma Germany Male pelvis 28 84
[9] Ehrhardt V (DEGRO, 2022)* The Possibility of AI-based Contours for Automatic Target Volume Determination in Adjuvant Radiotherapy of Breast cancer Germany Breast 79 178
[10] Melerowitz L (DEGRO, 2022)* Development of an AI-based Auto-Contouring of Upper and Lower Jaw Segments to the Optimized

Radiation Planning and Prosthetic Rehabilitation of Patients With Head and Neck Tumors

Germany Jaws 20 240
[11] Mehrhof F

(DEGRO, 2022)*

Establishment of an AI-Based Contouring of Cardiac Substructures in the Adjuvant Irradiation of Breast Cancer Germany Heart 20 80
[12] BergengrĂĽn PM (DEGRO, 2022)* Auto-Contouring of Cardiac Substructures: Volume and Dose to RIVA in Adjuvant Radiotherapy Following Breast-Conserving Surgery of Breast Cancer Germany Heart 51 51
[13] Wowk A (ESTRO, 2023) Introduction of AI Segmentation to Drive Improvements in Breast Cancer Radiotherapy UK Breast 30 NA
[14] Rasmussen ME (ESTRO, 2023) Benefit of AI-Assisted Organ-at-Risk Contouring in Head-and-Neck Cancer: A Global Randomized Study Albania

Argentina

Azerbaijan

Bangladesh

Belarus

Belgium

CostaRica

Denmark

Georgia

India

Indonesia

Jordan

Kazakhstan

Kenya

Kyrgyzstan

Malaysia

Mongolia

Nepal

North Macedonia

Pakistan

Republic of Moldova

Sudan

Tunisia

Uganda

Head and Neck 4 376
[15] Turcas A (ESTRO, 2023) Deep Learning-Based Automatic Segmentation for Brain OARs: Accuracy and Dosimetric Impact** Romania Brain 30 660
[16] Perez- Sanchez J (AAPM, 2023) Clinical Evaluation of Deep Learning-Based Auto-Segmentation in MRI-Only Prostate Radiotherapy USA Male pelvis 10 50
[17] Bordigioni B

(Corso di laurea in fisica medicale, 2023)

Automated Segmentation in Pelvic Radiotherapy: Implementation and Evaluation of Atlas-, Machine Learning-, and Deep Learning-Based Models. Italy Female pelvis;

Male pelvis

40 280

Notes: *Articles in German. **Most of the data are common in the full text article and the poster.

Abbreviations: NA – Not available in the published text; IAEA-ICARO-3 – International Atomic Energy Agency – International Conference on advances in Radiation Oncology; SEOR – Spanish Radiation Oncology Society; DEGRO – German Radiation Oncology Society; ESTRO – European Society for Therapeutic Radiology and Oncology; AAPM – American Associations of Physicists in Medicine; OARs – organs at risk; CE – European certification for safety, health and environmental protection requirements; FDA – Food and Drug Administration; CT – Computed Tomography; MRI – Magnetic Resonance Imaging; AI – Artificial Intelligence; RIVA – ramus intervetricularis anterior.

Excerpts from the scientific reports:

  • Using a general deep learning-based automated segmentation tool*** for CT images saves time and improves consistency [1].
  • Using small single-institutional radiotherapy datasets with consistently-defined rectal volumes when training auto segmentation algorithms created contours of similar quality as the same algorithm trained on large multi institutional datasets [2].
  • The application of the deep learning tool*** resulted satisfactory, especially in complex delineation cases, improving the radiation oncologists’ inter-agreement of delineated volumes of interest and saving time [3].
  • Auto-segmentation*** was significantly faster, with minor differences in dose distribution caused by geometric variations [4].
  • MVision offered 143 CT contours with a median vDSCs 0.88 and substantial time savings: on average 43.6 minutes  across all structures [5].
  • Contouring time is reduced when using auto-contouring solutions. The structure definition in the training set is important [6].
  • MVision significantly contributed to reducing contouring time, enhancing patient care by shortening their waiting times [7].
  • AI-based*** target volumes have a great resemblance to the original ones. As part of the Irradiation of localized prostate cancer, autocontouring is promising and provides a time-saving approach to target volume definition [8].
  • The AI-based contours*** show great resemblance both in the total volumes and in the DSC with the original medical contours [9].
  • The developed AI-based model*** of the jawbones is precise, time-efficient and shows good results in CTs with and without metal artifacts. The new jaw model presents a practical and economical option for radiation oncologists and oral and maxillofacial surgeons is the radiation dose in implant-relevant areas potentially reducing jaw segments [10].
  • An AI-based auto-contouring algorithm*** for cardiac substructures enable time-effective creation of contours for right ventricle, left ventricle, right atrium and left atrium in the context of thoracic radiation planning. The use of the algorithm enables retrospective and prospective analyses of the dose load of cardiac substructures in the context of thoracic radiation and enables a user-independent, automated contour creation [11].
  • AI-based contouring*** leads to more accurate and better reproducible contouring of organs at risk [12].
  • Use of AI volumes*** for breast patients requiring nodal treatment has streamlined the existing Breast/Chest wall ±axilla and supraclavicular fossa carepath, and accelerated VMAT roll-out for all high-risk breast patients, with anticipated toxicity reduction. An increase in confidence for dosimetrists in nodal plan optimization has reduced routine tasks requiring clinician input [13].
  • AI-assisted contouring*** significantly reduced inter observer variability across multiple institutions located in low and middle income countries globally. The results add a significant piece of evidence favoring further adoption of AI-assisted contouring worldwide [14].
  • AI-based segmentation*** is significantly faster than manual delineation. The geometric accuracy is high for large structures, which are also the most laborious to manually delineate [15].
  • The auto-segmentation models*** demonstrated superior accuracy and a high degree of consistency, offering the potential for significant time saving in contour delineation [16].
  • Deep learning-based auto-contouring*** outperformed STAPLE and random forest algorithms in cervical cancer, especially in rectum and bladder. (…) The strong time reduction could suggest an easier deep learning algorithm introduction in radiotherapy workflow, thanks also to the possibility to automate it [17].

Notes: the number in brackets refers to the corresponding article in the table. ***general terms referring to the evaluated solution, provided by MVision AI

Abbreviations: vDSC – volumetric Dice Similarity Coefficient – a measure of the similarity between the automated contour and the reference contour; VMAT – volumetric modulated arc therapy; STAPLE – Simultaneous Truth And Performance Level Evaluation.

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